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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists inembryonic and adult mammalian heart

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: of mononuclear diploid cardiomyocytes (MNDCMs), with regeneration potential, could persist in adult mammalian645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing    

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High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library Article

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Engineering 2021, Volume 7, Issue 11,   Pages 1557-1565 doi: 10.1016/j.eng.2020.11.011

Abstract:

Immunotherapy with anti-programmed cell death protein-1 (PD-1)/programmed cell death ligandThe PD-1/PD-L1 pathway inhibits T cell activation in the micro-environment, making it anPD-1 and its ligands (i.e., PD-L1 and PD-L2) or antibody (Opdivo), a small-content, epitope-oriented mammaliancell library was established for PD-1.After three rounds of cell sorting, the decoy PD-1 mutant 463, which presented a higher affinity than

Keywords： Decoy PD-1     PD-L1     Mammalian cell library     Epitope-oriented    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract:

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animalshave been exerted to trace the origin of the limited vestibular regeneration in mammals after hair cellMoreover, recently many strategies have been developed to promote the hair cell regeneration and subsequentThis article provides an overview of the recent advances in hair cell regeneration in mammalian vestibularFurthermore, this review highlights the current limitations of hair cell regeneration and provides the

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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Low-cost green building practice in China: Library of Shandong Transportation College

Yingxin ZHU, Borong LIN, Bin YUAN,

Frontiers in Energy 2010, Volume 4, Issue 1,   Pages 100-105 doi: 10.1007/s11708-009-0072-3

Abstract: This paper introduces the design idea and technique utilized in the Library of Shandong TransportationAfter reconstruction, it was changed into the construction site of the library with an area of 7000

Keywords： green building     low cost technique     energy efficiency     integrated strategy    

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Current techniques for assessing developmental neurotoxicity of pesticides

GAO Yu, TIAN Ying, SHEN Xiaoming

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 337-343 doi: 10.1007/s11684-008-0064-4

Abstract: These include: (1) techniques (PC12 cells, C6 cells and other cell models); (2) Non-mammalian models(sea urchins, zebrafish and other non-mammalian models); and (3) mammalian models (morphological techniques

Keywords： paradigms     Pyrethroids     non-mammalian     susceptible     morphological    

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software for land use regression modeling the spatial distribution of air pollutants using GDAL/OGR library

Xuying Ma, Ian Longley, Jennifer Salmond, Jay Gao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1221-5

Abstract: PyLUR comprises four modules for developing and applying a LUR model. It considers both conventional and novel potential predictor variables. GDAL/OGR libraries are used to do spatial analysis in the modeling and prediction. Developed on Python platform, PyLUR is rather efficient in data processing. Land use regression (LUR) models have been widely used in air pollution modeling. This regression-based approach estimates the ambient pollutant concentrations at un-sampled points of interest by considering the relationship between ambient concentrations and several predictor variables selected from the surrounding environment. Although conceptually quite simple, its successful implementation requires detailed knowledge of the area, expertise in GIS, statistics, and programming skills, which makes this modeling approach relatively inaccessible to novice users. In this contribution, we present a LUR modeling and pollution-mapping software named PyLUR. It uses GDAL/OGR libraries based on the Python platform and can build a LUR model and generate pollutant concentration maps efficiently. This self-developed software comprises four modules: a potential predictor variable generation module, a regression modeling module, a model validation module, and a prediction and mapping module. The performance of the newly developed PyLUR is compared to an existing LUR modeling software called RLUR (with similar functions implemented on R language platform) in terms of model accuracy, processing efficiency and software stability. The results show that PyLUR out-performs RLUR for modeling in the Bradford and Auckland case studies examined. Furthermore, PyLUR is much more efficient in data processing and it has a capability to handle detailed GIS input data.

Keywords： LUR     Air pollution modelling     GIS spatial analysis     GDAL/OGR Python     Pollutant concentration mapping    

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Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 128-135 doi: 10.1007/s11705-021-2080-8

Abstract: In this work, we have optimised a general and straightforward synthetic approach to prepare a small library

Keywords： fluorescence     probes     iron     screening     library    

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Intelligent Model Library for Nonferrous Metal Industry: Construction Method and Application

Yang Chunhua, Liu Yishun, Huang Keke, Sun Bei, Li Yonggang, Chen Xiaofang, Gui Weihua

Strategic Study of CAE 2022, Volume 24, Issue 4,   Pages 188-201 doi: 10.15302/J-SSCAE-2022.04.013

Abstract: Nonferrous metals industry intelligent model library architecture based on IIoT.The target environment can parse the PMML library to load the meta-model.Nonferrous metallurgy meta-model ontology library.Nonferrous metal industry intelligent model library.Currently, 1251 meta-models are available from this library.

Keywords： nonferrous metal industry     industrial software     meta-model     intelligent model library     industrial Internet    

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Construction, characterization and application of a genome-wide promoter library in

Ting Yuan,Yakun Guo,Junkai Dong,Tianyi Li,Tong Zhou,Kaiwen Sun,Mei Zhang,Qingyu Wu,Zhen Xie,Yizhi Cai,Limin Cao,Junbiao Dai

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 107-116 doi: 10.1007/s11705-017-1621-7

Abstract: Here we report the construction of a genome-wide promoter library, in which each native promoter inUsing fluorescence activated cell sorting, we classified the yeast strains based on YFP fluorescenceintensity and arbitrarily divided the entire library into 12 bins, representing weak to strong promotersTogether, this library could provide a quick solution to identify and utilize desired promoters under

Keywords： synthetic biology     yeast     promoter activity     metabolic engineering     xylose utilization    

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Adult Mammalian Neurogenesis: Hopes and Challenges in the Repair of Spinal Cord Injury

Zhaoyang Yang, Wen Zhao, Yudan Gao, Hongmei Duan, Peng Hao,  Fei Hao, Xiaoguang Li

Engineering 2021, Volume 7, Issue 12,   Pages 1713-1714 doi: 10.1016/j.eng.2021.09.009

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Analytical solutions of three-dimensional contaminant transport in uniform flow field in porous media: A library

Hongtao WANG, Huayong WU

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 1,   Pages 112-128 doi: 10.1007/s11783-008-0067-z

Abstract: The purpose of this study is to present a library of analytical solutions for the three-dimensional contaminantThe library is constructed using Green's function method (GFM) in combination with available solutionsThe library covers a wide range of solutions for various conditions.The library is widely applicable to solve contaminant transport problems of one- or multiple- dimensions

Keywords： solution library     contaminant transport     analytical solution     dispersion and advection     porous media     type    

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip     co-culture     cell-cell interactions     review    

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase     ubiquitination     T cell activation     T cell differentiation     T cell tolerance    

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering     surface display     whole-cell catalysts     bioprocess    

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A bacterial artificial chromosome-based physical map of

Yuhua FU,Zhiqiang XIA,Shujuan WANG,Xin CHEN,Cheng LU,Mingcheng LUO,Hongbin ZHANG,Wenquan WANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 321-329 doi: 10.15302/J-FASE-2016124

Abstract: The RI library has 29952 clones with an average insert size of 115 kb, while the dIII library consists

Keywords： cassava     BAC library     physical map    

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Title Author Date Type Operation

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists inembryonic and adult mammalian heart

Journal Article

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Low-cost green building practice in China: Library of Shandong Transportation College

Yingxin ZHU, Borong LIN, Bin YUAN,

Journal Article

Current techniques for assessing developmental neurotoxicity of pesticides

GAO Yu, TIAN Ying, SHEN Xiaoming

Journal Article

software for land use regression modeling the spatial distribution of air pollutants using GDAL/OGR library

Xuying Ma, Ian Longley, Jennifer Salmond, Jay Gao

Journal Article

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Journal Article

Intelligent Model Library for Nonferrous Metal Industry: Construction Method and Application

Yang Chunhua, Liu Yishun, Huang Keke, Sun Bei, Li Yonggang, Chen Xiaofang, Gui Weihua

Journal Article

Construction, characterization and application of a genome-wide promoter library in

Ting Yuan,Yakun Guo,Junkai Dong,Tianyi Li,Tong Zhou,Kaiwen Sun,Mei Zhang,Qingyu Wu,Zhen Xie,Yizhi Cai,Limin Cao,Junbiao Dai

Journal Article

Adult Mammalian Neurogenesis: Hopes and Challenges in the Repair of Spinal Cord Injury

Zhaoyang Yang, Wen Zhao, Yudan Gao, Hongmei Duan, Peng Hao,  Fei Hao, Xiaoguang Li

Journal Article

Analytical solutions of three-dimensional contaminant transport in uniform flow field in porous media: A library

Hongtao WANG, Huayong WU

Journal Article

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Journal Article

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Journal Article

Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Journal Article

A bacterial artificial chromosome-based physical map of

Yuhua FU,Zhiqiang XIA,Shujuan WANG,Xin CHEN,Cheng LU,Mingcheng LUO,Hongbin ZHANG,Wenquan WANG

Journal Article